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Limited use of potent topical steroids does not affect the h
High-potency topical corticosteroid cream (0.1% fluocinonide) used once a day in two weeks does not appear to affect the hypothalamus in children, new research suggests. However, when applied twice a day suppression of the hypothalamus was seen in children aged 6-17 years. No suppression was seen in the younger age groups.
Suppression of the hypothalamic-pituitary-adrenal (HPA) axis has been linked with an increased risk of growth retardation.
126 children between 3 months and 17 years old took part in the study, all with atopic dermatis covering at least 20% of their body surface area.
References: Schlessinger, J. et al. An Open-label Adrenal Suppression Study of 0.1% Fluocinonide Cream in Pediatric Patients With Atopic Dermatitis. Archives of Dermatology. 2006;142(12): 1568-1572. Accessed February 2nd., 2007 at www.medscape.com
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